Nrf2 activator
There is evidence that Nrf2-mediated attenuation of oxidative stress and suppression of inflammatory response could be partially responsible for resveratrol’s potential chemo preventive effects. Resveratrol has also been shown to increase the protein and mRNA expression of Nrf2. Pterostilbene, a naturally occurring phenolic compound/analog of resveratrol that has comparatively better oral bioavailability, has been shown to possess cytotoxic, anti-inflammatory, and antioxidant properties. Sulforaphane, through induction of Nrf2-dependent phase 2 enzyme, protects the brain against hypoxic-ischemic injury and may improve cognitive function when administered following traumatic brain injury. SGS may modify critical cysteine residues of Keap1, leading to Nrf2 stabilization and activation of the ARE, inducing phase 2 enzymes. Under this circumstance, Nrf2 then up-regulates a variety of antioxidant enzymes and detoxifying proteins.Ī variety of natural substances have been shown to activate Nrf2: Sulforaphane (SGS), a naturally occurring isothiocyanate derived from cruciferous vegetables, induces phase 2 cytoprotective enzymes, supporting the body’s response to oxidative stress and inflammation. This action stabilizes Nrf2, allowing it to accumulate in the nucleus and bind to the Antioxidant Response Element (ARE) located in the enhancers of its target genes. In the presence of any of these substances, Keap1 gives up its inhibition of Nrf2. Keap1 functions as a sensor for oxidants and electrophilic xenobiotics.
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In an unstressed state, Nrf2 is anchored in the cytoplasm by its specific inhibitor, Keap1 (Kelch-like ECH-Associated Protein 1). Nrf2 (NF-E2-Related Factor 2) , a transcription factor in humans that is encoded by the NFE2L2 gene, regulates the expression of a set of antioxidant and detoxifying genes, protecting the body from the ravages of oxidative stress-related conditions, including (but not limited to) those effecting the brain and nervous system. Take one or two capsules daily or as directed by your healthcare practitioner.